Control of cell differentiation by mechanical stress
نویسندگان
چکیده
منابع مشابه
Cell differentiation by mechanical stress.
Growth factors, hormones, and other regulatory molecules are traditionally required in tissue engineering studies to direct the differentiation of progenitor cells along specific lineages. We demonstrate that mechanical stimulation in vitro, without ligament-selective exogenous growth and differentiation factors, induces the differentiation of mesenchymal progenitor cells from the bone marrow i...
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در این پایان نامه، درهمتنیدگی بین یک سیستم نقطه کوانتومی دوگانه(مولکول نقطه کوانتومی) و میدان مورد مطالعه قرار گرفته است. از آنتروپی ون نیومن به عنوان ابزاری برای بررسی درهمتنیدگی بین اتم و میدان استفاده شده و تاثیر پارامترهای مختلف، نظیر تونل زنی(که توسط تغییر ولتاژ ایجاد می شود)، شدت میدان و نسبت دو گسیل خودبخودی بر رفتار درجه درهمتنیدگی سیستم بررسی شده اشت.با تغییر هر یک از این پارامترها، در...
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Numerous studies have focused on identifying the chemical and biological factors that govern the differentiation of stem cells; however, recent research has shown that mechanical cues may play an equally important role. Mechanical forces such as shear stresses and tensile loads, as well as the rigidity and topography of the extracellular matrix were shown to induce significant changes in the mo...
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Acknowledgements I would like to thank many people who have helped me through the completion of this thesis. The first is my advisor, Dr. Sabrina Jedlicka, for fostering my young research career in her biomaterials at Lehigh University. Additionally, the mentorship of Dr. Susan Perry was instrumental to me throughout my time at Lehigh, and her continued advice is invaluable. I have worked with ...
متن کاملMicrofluidic assessment of mechanical cell damage by extensional stress.
Mammalian cells have been widely used in bioreactors to produce biological products such as pharmaceutical materials. The productivity of such bioreactors is vastly affected by flow-induced cell damage in complicated flow environments, such as agitation-driven turbulence and oxygen bubble bursting at the interface between the culturing medium and air. However, there is no systematic approach to...
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ژورنال
عنوان ژورنال: The Journal of Physical Fitness and Sports Medicine
سال: 2013
ISSN: 2186-8131
DOI: 10.7600/jpfsm.2.49